Cellular mechanisms of contractile dysfunction in human heart failure
نویسندگان
چکیده
منابع مشابه
Cellular mechanisms of contractile dysfunction in human heart failure.
Numerous cellular abnormalities of heart muscle are associated with ventricular dysfunction and the clinical syndrome of heart failure. Many of these changes have been described in animal models of heart failure where there is considerable species and model variation''. The increasing use of cardiac transplantation has provided access to fresh myocardial tissue from severely failing human heart...
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A number of molecular and cellular alterations have been identified in the failing human heart that help to understand contraction and relaxation abnormalities. Cyclic AMP dependent pathways are desensitized due to quantitative changes in beta-adrenoceptors, beta-adrenoceptor kinase, and inhibitory G-proteins. Calcium homeostasis is impaired, characterized by a decreased calcium reuptake rate o...
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The cellular mechanisms underlying the development of congestive heart failure (HF) are not well understood. Accordingly, we studied myocardial function in isolated right ventricular trabeculae from rats in which HF was induced by left ventricular myocardial infarction (MI). Both early-stage (12 wk post-MI; E-pMI) and late, end-stage HF (28 wk post-Mi; L-pMI) were studied. HF was associated wit...
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Ischemic heart disease is a leading cause of chronic heart failure. Hibernation (ie, a chronic reduction of myocardial contractility distal to a severe coronary stenosis and reversible on revascularization) is an important contributing factor. The underlying cellular mechanisms remain however poorly understood. In young pigs (n=13, ISCH), an acquired coronary stenosis >90% (4 to 6 weeks) result...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 1996
ISSN: 0195-668X,1522-9645
DOI: 10.1093/oxfordjournals.eurheartj.a014834